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Thesis

Vaccine design for global health pathogens

Abstract:

MERS and malaria are two global infectious diseases with no commercial vaccines available. This thesis describes work undertaken to develop and improve adenovirus-based vaccines for these infectious diseases.

In the case of MERS coronavirus, a highly effective heterologous prime-boost vaccination based on a chimpanzee adenovirus was created (ChAdOx1). In order to further optimise its immunogenicity, previously described genetic designs modulating transgene expression were evaluated...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
CONACYT Mexico, The Jenner Institute (University of Oxford) More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Deposit date:
2021-01-20

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