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Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform

Abstract:

Epigenetic modifications of histone tails play an essential role in the regulation of eukaryotic transcription. Writer and eraser enzymes establish and maintain the epigenetic code by creating or removing posttranslational marks. Specific binding proteins, called readers, recognize the modifications and mediate epigenetic signalling. Here, we present a versatile assay platform for the investigation of the interaction between methyl lysine readers and their ligands. This can be utilized for th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw089

Authors


Greschik, H More by this author
Burgahn, T More by this author
Schmidtkunz, K More by this author
Schott, AK More by this author
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NIGMS NIH HHS More from this funder
European Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
44
Issue:
9
Publication date:
2016-05-05
DOI:
ISSN:
1362-4962 and 0305-1048
Pubs id:
pubs:605955
URN:
uri:1016b768-9537-473e-8e4e-c8cf065bf89e
UUID:
uuid:1016b768-9537-473e-8e4e-c8cf065bf89e
Local pid:
pubs:605955
Language:
English
Keywords:

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