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Sequential displacement of Type VI Secretion System effector genes leads to evolution of diverse immunity gene arrays in Vibrio cholerae

Abstract:

Type VI secretion systems (T6SS) enable bacteria to engage neighboring cells in contact-dependent competition. In Vibrio cholerae, three chromosomal clusters each encode a pair of effector and immunity genes downstream of those encoding the T6SS structural machinery for effector delivery. Different combinations of effector-immunity proteins lead to competition between strains of V. cholerae, which are thought to be protected only from the toxicity of their own effectors. Screening of all publ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep45133

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Department:
Wolfson College
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
Article: 45133
Publication date:
2017-03-22
DOI:
ISSN:
2045-2322
Pubs id:
pubs:687340
URN:
uri:0ff8c05e-a006-4deb-96fb-bf7345eee845
UUID:
uuid:0ff8c05e-a006-4deb-96fb-bf7345eee845
Local pid:
pubs:687340
Language:
English

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