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Journal article

YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function

Abstract:

With advances in sequencing technology, uncharacterized proteins and domains of unknown function (DUFs) are rapidly accumulating in sequence databases and offer an opportunity to discover new protein chemistry and reaction mechanisms. The focus of this review, the formerly enigmatic YcaO superfamily (DUF181), has been found to catalyze a unique phosphorylation of a ribosomal peptide backbone amide upon attack by different nucleophiles. Established nucleophiles are the side chains of Cys, Ser,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.chemrev.6b00623

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Department:
Oxford, MSD, NDM
Role:
Author
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Funding agency for:
Naismith, JH
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Funding agency for:
Naismith, JH
Publisher:
American Chemical Society Publisher's website
Journal:
Chemical Reviews Journal website
Volume:
117
Issue:
8
Pages:
5389-5456
Publication date:
2017-04-26
DOI:
EISSN:
1520-6890
ISSN:
0009-2665
Pubs id:
pubs:699004
URN:
uri:0fec3ed7-cb1d-4c68-84a2-32e96145b4a6
UUID:
uuid:0fec3ed7-cb1d-4c68-84a2-32e96145b4a6
Local pid:
pubs:699004
Paper number:
8
Language:
English

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