Journal article
YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function
- Abstract:
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With advances in sequencing technology, uncharacterized proteins and domains of unknown function (DUFs) are rapidly accumulating in sequence databases and offer an opportunity to discover new protein chemistry and reaction mechanisms. The focus of this review, the formerly enigmatic YcaO superfamily (DUF181), has been found to catalyze a unique phosphorylation of a ribosomal peptide backbone amide upon attack by different nucleophiles. Established nucleophiles are the side chains of Cys, Ser,...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 2.3MB)
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- Publisher copy:
- 10.1021/acs.chemrev.6b00623
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Authors
Funding
+ European Research Council
More from this funder
Funding agency for:
Naismith, J
Grant:
Wolfson Merit Award Holder
+ Biotechnology and
Biological Sciences Research Council
More from this funder
Funding agency for:
Naismith, J
Grant:
Wolfson Merit Award Holder
+ Royal Society
More from this funder
Funding agency for:
Naismith, J
Grant:
Wolfson Merit Award Holder
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Chemical Reviews Journal website
- Volume:
- 117
- Issue:
- 8
- Pages:
- 5389-5456
- Publication date:
- 2017-04-26
- Acceptance date:
- 2017-03-03
- DOI:
- EISSN:
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1520-6890
- ISSN:
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0009-2665
- Source identifiers:
-
699004
Item Description
- Language:
- English
- Pubs id:
-
pubs:699004
- UUID:
-
uuid:0fec3ed7-cb1d-4c68-84a2-32e96145b4a6
- Local pid:
- pubs:699004
- Deposit date:
- 2017-07-24
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acs.chemrev.6b00623
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