Journal article icon

Journal article

YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function

Abstract:

With advances in sequencing technology, uncharacterized proteins and domains of unknown function (DUFs) are rapidly accumulating in sequence databases and offer an opportunity to discover new protein chemistry and reaction mechanisms. The focus of this review, the formerly enigmatic YcaO superfamily (DUF181), has been found to catalyze a unique phosphorylation of a ribosomal peptide backbone amide upon attack by different nucleophiles. Established nucleophiles are the side chains of Cys, Ser,...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.chemrev.6b00623

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More from this funder
Funding agency for:
Naismith, J
Grant:
Wolfson Merit Award Holder
More from this funder
Funding agency for:
Naismith, J
Grant:
Wolfson Merit Award Holder
More from this funder
Funding agency for:
Naismith, J
Grant:
Wolfson Merit Award Holder
Publisher:
American Chemical Society Publisher's website
Journal:
Chemical Reviews Journal website
Volume:
117
Issue:
8
Pages:
5389-5456
Publication date:
2017-04-26
Acceptance date:
2017-03-03
DOI:
EISSN:
1520-6890
ISSN:
0009-2665
Source identifiers:
699004
Language:
English
Pubs id:
pubs:699004
UUID:
uuid:0fec3ed7-cb1d-4c68-84a2-32e96145b4a6
Local pid:
pubs:699004
Deposit date:
2017-07-24

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP