- Abstract:
-
With advances in sequencing technology, uncharacterized proteins and domains of unknown function (DUFs) are rapidly accumulating in sequence databases and offer an opportunity to discover new protein chemistry and reaction mechanisms. The focus of this review, the formerly enigmatic YcaO superfamily (DUF181), has been found to catalyze a unique phosphorylation of a ribosomal peptide backbone amide upon attack by different nucleophiles. Established nucleophiles are the side chains of Cys, Ser,...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 2.3MB)
-
- Publisher copy:
- 10.1021/acs.chemrev.6b00623
-
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- Funding agency for:
- Naismith, JH
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Chemical Reviews Journal website
- Volume:
- 117
- Issue:
- 8
- Pages:
- 5389-5456
- Publication date:
- 2017-04-26
- DOI:
- EISSN:
-
1520-6890
- ISSN:
-
0009-2665
- Pubs id:
-
pubs:699004
- URN:
-
uri:0fec3ed7-cb1d-4c68-84a2-32e96145b4a6
- UUID:
-
uuid:0fec3ed7-cb1d-4c68-84a2-32e96145b4a6
- Local pid:
- pubs:699004
- Paper number:
- 8
- Language:
- English
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acs.chemrev.6b00623
Journal article
YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function
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Biological Sciences Research Council
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