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Journal article

A phase-I trial of pre-operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the 'SPARC' trial protocol.

Abstract:

BACKGROUND: Standard therapy for borderline-resectable pancreatic cancer in the UK is surgery with adjuvant chemotherapy, but rates of resection with clear margins are unsatisfactory and overall survival remains poor. Meta-analysis of single-arm studies shows the potential of neo-adjuvant chemo-radiotherapy but the relative radio-resistance of pancreatic cancer means the efficacy of conventional dose schedules is limited. Stereotactic radiotherapy achieves sufficient accuracy and precision to...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12885-016-2765-4

Authors


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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
McIntosh, D More by this author
Sebag-Montefiore, D More by this author
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Grant:
C43735/A18787; Fellowship C5255
Publisher:
BioMed Central Publisher's website
Journal:
BMC Cancer Journal website
Volume:
16
Issue:
1
Pages:
728
Publication date:
2016-09-13
Acceptance date:
2016-08-17
DOI:
EISSN:
1471-2407
ISSN:
1471-2407
Pubs id:
pubs:644306
URN:
uri:0f898445-7ac5-4cd8-adff-012f8ab79f4a
UUID:
uuid:0f898445-7ac5-4cd8-adff-012f8ab79f4a
Local pid:
pubs:644306

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