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A review of Phase I trials of Ebolavirus vaccines: What can we learn from the race to develop novel vaccines?

Abstract:

Sporadic outbreaks of Ebolavirus infection have been documented since the mid-seventies and viral exposure can lead to lethal haemorrhagic fever with case fatalities as high as 90%. There is now a comprehensive body of data from both ongoing and completed clinical trials assessing various vaccine strategies, which were rapidly advanced through clinical trials in response to the 2014 EVD public health emergency. Careful consideration of immunogenicity post-vaccination is essential but has be...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rstb.2016.0295

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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions B: Biological Sciences Journal website
Volume:
372
Issue:
1721
Pages:
20160295
Publication date:
2017-04-10
Acceptance date:
2016-11-17
DOI:
EISSN:
0962-8436
ISSN:
1471-2970
Pubs id:
pubs:660141
URN:
uri:0f724992-b112-445f-bab7-d4f9a4702d9c
UUID:
uuid:0f724992-b112-445f-bab7-d4f9a4702d9c
Local pid:
pubs:660141
Paper number:
1721

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