Journal article
Progress and outlook in studying the substrate specificities of PARPs and related enzymes
- Abstract:
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Despite decades of research on ADP‐ribosyltransferases (ARTs) from the poly(ADP‐ribose) polymerase (PARP) family, one key aspect of these enzymes – their substrate specificity – has remained unclear. Here, we briefly discuss the history of this area and, more extensively, the recent breakthroughs, including the identification of protein serine residues as a major substrate of PARP1 and PARP2 in human cells and of cysteine and tyrosine as potential targets of specific PARPs. On the molecular l...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 551.6KB, Terms of use)
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- Publisher copy:
- 10.1111/febs.15518
Authors
Bibliographic Details
- Publisher:
- Wiley
- Journal:
- FEBS Journal More from this journal
- Volume:
- 288
- Issue:
- 7
- Pages:
- 2131-2142
- Publication date:
- 2020-08-29
- Acceptance date:
- 2020-08-12
- DOI:
- EISSN:
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1742-4658
- ISSN:
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1742-464X
- Pmid:
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32785980
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1126423
- Local pid:
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pubs:1126423
- Deposit date:
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2020-09-22
Terms of use
- Copyright holder:
- Suskiewicz et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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