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Heterocyclic allylsulfones as latent heteroaryl nucleophiles in palladium-catalyzed cross-coupling reactions

Abstract:

Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. However, the preparation and purification of complex heterocylic sulfinates can be problematic. In addition, sulfinate functionality is not tolerant to the majority of synthetic transformations, making these reagents unsuitable for multistep elaboration. Herein, we show that heterocyclic allylsulfones can function as lat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/jacs.8b09595

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
Shavnya, A More by this author
Blakemore, D More by this author
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
140
Issue:
46
Pages:
15916-15923
Publication date:
2018-11-09
Acceptance date:
2018-10-31
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:935976
URN:
uri:0f32f36f-fbe0-497a-92ca-2e21f89c2f11
UUID:
uuid:0f32f36f-fbe0-497a-92ca-2e21f89c2f11
Local pid:
pubs:935976

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