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Modernised classification of cardiac anti-arrhytmic drugs

Abstract:

Amongst his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918-2016) provided a classification of anti-arrhythmic drugs that remains central to their clinical use. On this centenary of his birth we survey the implications of subsequent discoveries concerning sarcolemmal, sarcoplasmic reticular and cytosolic biomolecules, to develop an expanded but pragmatic classification that encompasses approved and potential anti-arrhythmic drugs. We first consider the range of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1161/CIRCULATIONAHA.118.035455

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
ORCID:
0000-0002-0928-341X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
Publisher:
American Heart Association Publisher's website
Journal:
Circulation Journal website
Volume:
138
Pages:
1879–1896
Publication date:
2018-10-22
Acceptance date:
2018-08-10
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pubs id:
pubs:920125
URN:
uri:0f2d1a37-99d3-46a8-9d03-269a1dc9a6c3
UUID:
uuid:0f2d1a37-99d3-46a8-9d03-269a1dc9a6c3
Local pid:
pubs:920125

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