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A high throughput screen for next-generation leads targeting malaria parasite transmission

Abstract:

Spread of parasite resistance to artemisinin threatens current frontline antimalarial therapies, highlighting the need for new drugs with alternative modes of action. Since only 0.2-1% of asexual parasites differentiate into sexual, transmission-competent forms, targeting this natural bottleneck provides a tangible route to interrupt disease transmission and mitigate resistance selection. Here we present a high-throughput screen of gametogenesis against a ~70,000 compound diversity library, i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-05777-2

Authors


Delves, MJ More by this author
Miguel-Blanco, C More by this author
Matthews, H More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
ORCID:
0000-0003-3804-9670
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Alfonso Martín Escudero Foundation More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
3805
Publication date:
2018-09-18
Acceptance date:
2018-07-26
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:920653
URN:
uri:0f2a693e-682a-45d6-ad81-e876ffc165f9
UUID:
uuid:0f2a693e-682a-45d6-ad81-e876ffc165f9
Local pid:
pubs:920653
Language:
English
Keywords:

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