Journal article
Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses
- Abstract:
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Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. We observed broad and potent ex vivo CD8+ T cell-mediated viral inhibitory activity against a panel of HIV isolates among viremic controllers (VC, viral loads <5000 copies/ml), in con...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 877.6KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.ppat.1004658
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Pathogens More from this journal
- Volume:
- 11
- Issue:
- 2
- Pages:
- e1004658
- Publication date:
- 2015-02-27
- Acceptance date:
- 2015-01-05
- DOI:
- EISSN:
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1553-7374
- ISSN:
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1553-7366
- Pmid:
-
25723536
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:508639
- UUID:
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uuid:0eec7bfa-47c1-4740-8fed-d1e4f620f0c7
- Local pid:
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pubs:508639
- Source identifiers:
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508639
- Deposit date:
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2017-01-03
Terms of use
- Copyright holder:
- Hancock et al
- Copyright date:
- 2015
- Notes:
- © 2015 Hancock et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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