Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
- Dynamic duo: The reversible reaction of boronic acids with alcohols to form boronate esters, coupled to protein mass spectrometry analyses, was used to discover potent oxygenase inhibitors. This dynamic combinatorial mass spectrometry technique could potentially be applied to the identification of other protein inhibitors. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
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