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Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Abstract:
Dynamic duo: The reversible reaction of boronic acids with alcohols to form boronate esters, coupled to protein mass spectrometry analyses, was used to discover potent oxygenase inhibitors. This dynamic combinatorial mass spectrometry technique could potentially be applied to the identification of other protein inhibitors. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201202000

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Journal:
Angewandte Chemie (International ed. in English)
Volume:
51
Issue:
27
Pages:
6672-6675
Publication date:
2012-07-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Source identifiers:
334704
Language:
English
Keywords:
Pubs id:
pubs:334704
UUID:
uuid:0ee6d569-7dd4-4287-a20f-464492ac351d
Local pid:
pubs:334704
Deposit date:
2012-12-19

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