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Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model

Abstract:

Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually1. The typhoid toxin is postulated to have a central role in disease pathogenesis, the establishment of chronic infection and human host restriction2-6. However, its precise role in typhoid disease in humans is not fully defined. We studied the role of typhoid toxin in acute infection using a randomized, double-blind S. Typhi human challenge model7. Forty hea...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41591-019-0505-4

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
ORCID:
0000-0003-1781-0053
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
St Cross College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Medicine Journal website
Volume:
25
Pages:
1082–1088
Publication date:
2019-07-03
Acceptance date:
2019-05-30
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pubs id:
pubs:1028223
URN:
uri:0eda47be-ad28-4a82-b9ed-50121c32748d
UUID:
uuid:0eda47be-ad28-4a82-b9ed-50121c32748d
Local pid:
pubs:1028223
Language:
English

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