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The worm has turned: unexpected similarities between the transcription of enhancers and promoters in the worm and mammalian genomes.

Abstract:

Our understanding of biological processes in humans is often based on examination of analogous processes in other organisms. The nematode worm Caenorhabditis elegans has been a particularly valuable model, leading to Nobel prize winning discoveries in development and genetics. Until recently, however, the worm has not been widely used as a model to study transcription due to the lack of a comprehensive catalogue of its RNA transcripts. A recent study by Chen et al. uses next-generation sequen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bies.201300105

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Weatherall Institute of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
Publisher:
Wiley Publisher's website
Journal:
BioEssays : news and reviews in molecular, cellular and developmental biology Journal website
Volume:
36
Issue:
2
Pages:
157-162
Publication date:
2014-02-05
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
URN:
uuid:0eae758c-0e42-4936-be72-041e98ff2d4d
Source identifiers:
441687
Local pid:
pubs:441687

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