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Significant linkage to migrane with aura on chromosome 11q24

Abstract:

Migraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare Mendelian form of MA, can be caused by mutations in the calcium channel gene, CACNA1A or in the ATP1A2 gene, a Na+/K+ pump. Susceptibility genes for the more prevalent forms of migraine have yet to be identified despite several reports of linkage including loci on 4q24, 1q31, 19p13 and Xq24-28. We have undertaken a genome-wide screen of 43 Canadian famil...

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Publisher copy:
10.1093/hmg/ddg252

Authors


Noble-Topham, S More by this author
Dyment, DA More by this author
Cherny, SS More by this author
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Journal:
Human Molecular Genetics
Volume:
12
Issue:
19
Pages:
2511-2517
Publication date:
2003-10-01
DOI:
ISSN:
0964-6906
URN:
uuid:0ea954b0-bc93-473d-928f-92b492f5706b
Source identifiers:
159678
Local pid:
pubs:159678
Language:
English

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