Journal article icon

Journal article

β-Cell dysfunction in diabetes: a crisis of identity?

Abstract:

Type 2 diabetes is characterized by insulin resistance and a progressive loss of β-cell function induced by a combination of both β-cell loss and impaired insulin secretion from remaining β-cells. Here, we review the fate of the β-cell under chronic hyperglycaemic conditions with regard to β-cell mass, gene expression, hormone content, secretory capacity and the ability to de- or transdifferentiate into other cell types. We compare data from various in vivo and in vitro models of diabetes wit...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1111/dom.12732

Authors


Brereton, MF More by this author
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More from this funder
Funding agency for:
Ashcroft, F
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Diabetes, Obesity and Metabolism Journal website
Volume:
18
Issue:
S1
Pages:
102-109
Publication date:
2016-09-12
Acceptance date:
2016-04-25
DOI:
EISSN:
1463-1326
ISSN:
1462-8902
Pubs id:
pubs:645855
URN:
uri:0e6d7727-b75b-4b00-9b07-41f348a25dfd
UUID:
uuid:0e6d7727-b75b-4b00-9b07-41f348a25dfd
Local pid:
pubs:645855

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP