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Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.

Abstract:

Recent studies using laboratory clones have demonstrated that several antiretroviral protease inhibitors (PIs) inhibit the growth of Plasmodium falciparum at concentrations that may be of clinical significance, especially during human immunodeficiency virus type 1 (HIV-1) and malaria coinfection. Using clinical isolates, we now demonstrate the in vitro effectiveness of two HIV-1 aspartic PIs, saquinavir (SQV) and ritonavir (RTV), against P. vivax (n = 30) and P. falciparum (n = 20) from popul...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00169-08

Authors


Lek-Uthai, U More by this author
Suwanarusk, R More by this author
Ruengweerayut, R More by this author
Skinner-Adams, TS More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
52
Issue:
7
Pages:
2435-2441
Publication date:
2008-07-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:0e60f289-4ca4-45e3-b250-84810ab96547
Source identifiers:
11641
Local pid:
pubs:11641

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