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β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

Abstract:

Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. Cyclin F has important functions in regulating the cell cycle during the G2 checkpoint; however, the mechanisms underlying the regulation of cyclin F are...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.08.076

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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More from this funder
Funding agency for:
Kessler, B
Grant:
097813/Z/11/Z
More from this funder
Funding agency for:
Kessler, B
Grant:
097813/Z/11/Z
More from this funder
Funding agency for:
D'Angiolella, V
Grant:
MC_U U_00001/7
Publisher:
Elsevier Publisher's website
Journal:
Cell reports Journal website
Volume:
24
Issue:
13
Pages:
3404-3412
Publication date:
2018-09-25
Acceptance date:
2018-08-24
DOI:
ISSN:
2211-1247
Pmid:
30257202
Source identifiers:
922109
Language:
English
Keywords:
Pubs id:
pubs:922109
UUID:
uuid:0e092b8f-37ba-44fe-993a-f73c0db5dfca
Local pid:
pubs:922109
Deposit date:
2018-09-30

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