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SYNTHESIS OF CYCLOPENTANE SPIROHYDANTOINS BY ALDOL CYCLIZATIONS - AN APPROACH TO HIGHLY SUBSTITUTED ALPHA-CYCLOPENTANE AMINO-ACIDS

Abstract:
Efficient but reversible aldol condensations of 2-azido-5-formyl-1,5-lactones provide short routes to precursors for α-cyclopentane amino acids, some aminopseudosugars and spirohydantoins of cyclopentanes with control of the stereochemistry at all 5 carbons bearing functional groups. The effects of some of the compounds on human liver-glycosidases are described. © 1993.
Publication status:
Published

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Journal:
TETRAHEDRON LETTERS
Volume:
34
Issue:
49
Pages:
7953-7956
Publication date:
1993-12-03
DOI:
ISSN:
0040-4039
URN:
uuid:0e00d0fc-4bba-4ffb-b6ea-dad6ecb0ac38
Source identifiers:
44375
Local pid:
pubs:44375
Language:
English

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