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Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

Abstract:

Rhomboids are intramembrane serine proteases conserved in all kingdoms of life. They regulate epidermal growth factor receptor signalling in Drosophila by releasing signalling ligands from their transmembrane tethers. Their functions in mammals are poorly understood, in part because of the lack of endogenous substrates identified thus far. We used a quantitative proteomics approach to investigate the substrate repertoire of rhomboid protease RHBDL2 in human cells. We reveal a range of novel s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-07556-3

Authors


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Role:
Author
ORCID:
0000-0002-2076-9891
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Role:
Author
ORCID:
0000-0002-4243-7193
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0003-0410-5451
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
Article: 7283
Publication date:
2017-08-04
Acceptance date:
2017-06-21
DOI:
ISSN:
2045-2322
Pubs id:
pubs:721535
URN:
uri:0df696b4-fd83-4a9e-8d47-d05e5a9644e6
UUID:
uuid:0df696b4-fd83-4a9e-8d47-d05e5a9644e6
Local pid:
pubs:721535
Paper number:
1
Language:
English

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