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Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation

Abstract:

Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin (UAG) possesses a unique activity spectrum that includes promoting bone marrow adipogenesis. Since a receptor mediating this action has not been identified, we re-appraised the potential interaction of UAG with GHS-R in the regulation of bone marrow adiposity. Surprisingly, the adipogenic effects of intra-bone marrow (ibm)-infused acylated ghrelin (AG) and UAG were abolished in male GHS-R-null mice. Gas ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep45541

Authors


Hopkins, AL More by this author
Nelson, TAS More by this author
Guschina, IA More by this author
Parsons, LC More by this author
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Cardiff School of Biosciences More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
45541
Publication date:
2017-03-31
Acceptance date:
2017-02-21
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:687748
URN:
uri:0d64e3a0-166e-48a9-b7b4-760cd9c98419
UUID:
uuid:0d64e3a0-166e-48a9-b7b4-760cd9c98419
Local pid:
pubs:687748

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