Journal article
A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion
- Abstract:
-
Glucagon-like peptide-1 (GLP-1) is an endogenous glucose-lowering hormone and GLP-1 receptor agonists are currently being used as antidiabetic drugs clinically. The canonical signalling pathway (including cAMP, Epac2, protein kinase A (PKA) and KATP channels) is almost universally accepted as the main mechanism of GLP-1-stimulated insulin secretion. This belief is based on in vitro studies that used nanomolar (1-100 nM) concentrations of GLP-1. Recently, it was found that the physiological co...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Accepted manuscript, pdf, 219.4KB)
-
- Publisher copy:
- 10.1007/s00109-017-1508-6
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Rorsman, P
Grant:
Senior Investigator Award
Bibliographic Details
- Publisher:
- Springer Berlin Heidelberg Publisher's website
- Journal:
- Journal of Molecular Medicine Journal website
- Volume:
- 95
- Issue:
- 4
- Pages:
- 361–368
- Publication date:
- 2017-01-17
- Acceptance date:
- 2016-11-30
- DOI:
- EISSN:
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1432-1440
- ISSN:
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0946-2716
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:672185
- UUID:
-
uuid:0d640519-07e1-4da6-b060-9fc9a76f2b20
- Local pid:
- pubs:672185
- Source identifiers:
-
672185
- Deposit date:
- 2017-02-21
Terms of use
- Copyright holder:
- Springer-Verlag Berlin Heidelberg
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Springer-Verlag Berlin Heidelberg. This is the accepted manuscript version of the article. The final version is available online from Springer at: https://doi.org/10.1007/s00109-017-1508-6
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