Journal article
Combined 1H-detected solid-state NMR spectroscopy and electron cryotomography to study membrane proteins across resolutions in native environments
- Abstract:
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Membrane proteins remain challenging targets for structural biology, despite much effort, as their native environment is heterogeneous and complex. Most methods rely on detergents to extract membrane proteins from their native environment, but this removal can significantly alter the structure and function of these proteins. Here, we overcome these challenges with a hybrid method to study membrane proteins in their native membranes, combining high-resolution solid-state nuclear magnetic reson...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 6.9MB)
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- Publisher copy:
- 10.1016/j.str.2017.11.011
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Authors
Funding
+ Canadian Institutes of Health Research
More from this funder
Funding agency for:
Baker, L
Grant:
Postdoctoral Fellowship
+ Human Frontier Science Program
More from this funder
Funding agency for:
Baker, L
Grant:
Postdoctoral Fellowship
+ Netherlands Organisation for Scientific Research
More from this funder
Grant:
700.10.443toM.B
700.26.121
+ Wellcome Trust
More from this funder
Funding agency for:
Grünewald, K
Grant:
Senior Research Fellowship (090895/Z/09/Z
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 26
- Issue:
- 1
- Pages:
- 161-170.e3
- Publication date:
- 2017-12-14
- Acceptance date:
- 2017-11-15
- DOI:
- EISSN:
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1878-4186
- ISSN:
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0969-2126
- Pmid:
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29249608
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:813191
- UUID:
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uuid:0d5344b8-4fde-4ff2-b7a7-3d81f5e584dc
- Local pid:
- pubs:813191
- Deposit date:
- 2018-09-11
Terms of use
- Copyright holder:
- Baker et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Elsevier Ltd. 161
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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