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Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics

Abstract:

Background: While a subgroup of patients with exacerbations of chronic obstructive pulmonary disease (COPD) clearly benefit from antibiotics, their identification remains challenging. We hypothesised that selective assessment of the balance between the two dominant bacterial groups (Gammaproteobacteria (G)...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0182833

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Kwambana, B More by this author
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Funding agency for:
Brightling, CE
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
8
Pages:
e0182833
Publication date:
2017-08-25
Acceptance date:
2017-07-25
DOI:
ISSN:
1932-6203
Pubs id:
pubs:724806
URN:
uri:0d4c5bbe-bfa3-4f4b-8b1c-bca33aeda596
UUID:
uuid:0d4c5bbe-bfa3-4f4b-8b1c-bca33aeda596
Local pid:
pubs:724806

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