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Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics

Abstract:

Background: While a subgroup of patients with exacerbations of chronic obstructive pulmonary disease (COPD) clearly benefit from antibiotics, their identification remains challenging. We hypothesised that selective assessment of the balance between the two dominant bacterial groups (Gammaproteobacteria (G) and Firmicutes (F)) in COPD sputum samples might reveal a subgroup with a bacterial community structure change at exacerbation that was restored to baseline on recovery and potentially ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Name:
Leicester Respiratory Biomedical Research Unit
Grant:
*Grant Number Example*
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Name:
Medical Research Council
Grant:
*Grant Number Example*
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Name:
Wellcome Trust
Funding agency for:
Brightling, CE
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Bafadhel, M
Brightling, CE
Publisher:
Public Library of Science
Journal:
PLoS One More from this journal
Volume:
12
Issue:
8
Pages:
e0182833
Publication date:
2017-08-25
Acceptance date:
2017-07-25
DOI:
ISSN:
1932-6203
Pubs id:
pubs:724806
UUID:
uuid:0d4c5bbe-bfa3-4f4b-8b1c-bca33aeda596
Local pid:
pubs:724806
Source identifiers:
724806
Deposit date:
2017-09-07

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