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Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics

Abstract:

Background: While a subgroup of patients with exacerbations of chronic obstructive pulmonary disease (COPD) clearly benefit from antibiotics, their identification remains challenging. We hypothesised that selective assessment of the balance between the two dominant bacterial groups (Gammaproteobacteria (G) and Firmicutes (F)) in COPD sputum samples might reveal a subgroup with a bacterial community structure change at exacerbation that was restored to baseline on recovery and potentially ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0182833

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Funding agency for:
Brightling, CE
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
8
Pages:
e0182833
Publication date:
2017-08-25
Acceptance date:
2017-07-25
DOI:
ISSN:
1932-6203
Source identifiers:
724806
Pubs id:
pubs:724806
UUID:
uuid:0d4c5bbe-bfa3-4f4b-8b1c-bca33aeda596
Local pid:
pubs:724806
Deposit date:
2017-09-07

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