Journal article
Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics
- Abstract:
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Background: While a subgroup of patients with exacerbations of chronic obstructive pulmonary disease (COPD) clearly benefit from antibiotics, their identification remains challenging. We hypothesised that selective assessment of the balance between the two dominant bacterial groups (Gammaproteobacteria (G) and Firmicutes (F)) in COPD sputum samples might reveal a subgroup with a bacterial community structure change at exacerbation that was restored to baseline on recovery and potentially ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.7MB)
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- Publisher copy:
- 10.1371/journal.pone.0182833
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Authors
Funding
+ Leicester Respiratory Biomedical Research Unit
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS One Journal website
- Volume:
- 12
- Issue:
- 8
- Pages:
- e0182833
- Publication date:
- 2017-08-25
- Acceptance date:
- 2017-07-25
- DOI:
- ISSN:
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1932-6203
- Source identifiers:
-
724806
Item Description
- Pubs id:
-
pubs:724806
- UUID:
-
uuid:0d4c5bbe-bfa3-4f4b-8b1c-bca33aeda596
- Local pid:
- pubs:724806
- Deposit date:
- 2017-09-07
Terms of use
- Copyright holder:
- © 2017 Haldar et al
- Copyright date:
- 2017
- Notes:
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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