Journal article
Fingerprinting bacterial metabolic response to erythromycin by Raman-integrated mid-infrared photothermal microscopy
- Abstract:
-
We report rapid and sensitive phenotyping of bacterial response to antibiotic treatment at single-cell resolution by a Raman-integrated optical mid-infrared photothermal (MIP) microscope. The MIP microscope successfully detected biochemical changes of bacteria in specific to the acting mechanism of erythromycin with 1 h incubation. Compared to Raman spectroscopy, MIP spectroscopy showed a much larger signal-to-noise ratio at the fingerprint region at an acquisition speed as fast as 1 s per sp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
NIGMS NIH HHS
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Analytical Chemistry Journal website
- Volume:
- 92
- Issue:
- 21
- Pages:
- 14459-14465
- Publication date:
- 2020-10-22
- Acceptance date:
- 2020-10-09
- DOI:
- EISSN:
-
1520-6882
- ISSN:
-
0003-2700
- Pmid:
-
33089997
Item Description
- Language:
- English
- Pubs id:
-
1139706
- Local pid:
- pubs:1139706
- Deposit date:
- 2021-02-13
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2020
- Rights statement:
- © 2020 American Chemical Society.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from the American Chemical Society at: https://doi.org/10.1021/acs.analchem.0c02489
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