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Thesis

Discovery of small molecule epigenetic modulators

Abstract:

Target validation is increasingly becoming a central tenet to successful execution of drug discovery campaigns. An emerging approach towards the development of novel therapies for previously untreated diseases is the development of small molecule chemical probes which can be used as early stage tools for pertinent biological questions to be explored about a molecular target within the context of disease. A number of proteins which regulate epigenetic mechanisms have been correlated with di...

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English

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