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Chemoprophlaxis trial designs in epidemics: insights from a systematic review of COVID-19 study registrations

Abstract:

Background
Chemoprophylactics against emerging epidemic and pandemic infectious diseases offer potential for prevention but require efficacy and safety analysis before widespread use can be recommended. Chemoprophylaxis with repurposed drugs enable deployment ahead of development of novel vaccines. It may have particular utility as a stopgap ahead of vaccine deployment or when vaccines become less effective on virus variants, in countries where there may be structura... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s13063-021-05323-4

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-9822-1586
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-2469-791X
More from this funder
Name:
Wellcome Trust
Grant:
215091/Z/18/Z
More from this funder
Name:
National Institute for Health Research
Grant:
EPIDZ034
Publisher:
BMC
Journal:
Trials More from this journal
Volume:
22
Issue:
2021
Article number:
370
Publication date:
2021-05-29
Acceptance date:
2021-05-11
DOI:
EISSN:
1745-6215
Language:
English
Keywords:
Pubs id:
1176647
Local pid:
pubs:1176647
Deposit date:
2021-05-17

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