Variation in the ICAM1 gene is not associated with severe malaria phenotypes.

Journal article

Evidence from autopsy and in vitro binding studies suggests that adhesion of erythrocytes infected with Plasmodium falciparum to the human host intercellular adhesion molecule (ICAM)-1 receptor is important in the pathogenesis of severe malaria. Previous association studies between polymorphisms in the ICAM1 gene and susceptibility to severe malarial phenotypes have been inconclusive and often contradictory. We performed genetic association studies with 15 single nucleotide polymorphisms (SNP...

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Authors: Fry, A; Auburn, S; Diakite, M; Green, A; Richardson, A

• Publication status: Published
• Journal: Genes and immunity
• Volume: 9
• Issue: 5
• Pages: 462-469
• Publication date: 2008-07-01
• DOI: 10.1038/gene.2008.38
• EISSN: 1476-5470
• ISSN: 1466-4879
• Language: English
• Keywords: Genetic Variation; Kenya; Phenotype; Malawi; Intercellular Adhesion Molecule-1; Polymorphism, Single Nucleotide; Gambia; Humans; Malaria