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Dehydrodieugenol B derivatives as antiparasitic agents: synthesis and biological activity against Trypanosoma cruzi

Abstract:

Chagas disease is a neglected protozoan disease that affects more than eight million people in developing countries. Due to the limited number and toxicity profiles of therapies in current use, new drugs are urgently needed. In previous studies, we reported the isolation of two related antitrypanosomal neolignans from Nectandra leucantha (Lauraceae). In this work, a semi-synthetic library of twenty-three neolignan derivatives was prepared to explore synthetically accessible structure activity...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ejmech.2019.05.001

Authors


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Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Sear, C
Grant:
EP/L015838/1
EP/M019195/1
Publisher:
Elsevier
Journal:
European Journal of Medicinal Chemistry More from this journal
Volume:
176
Pages:
162-174
Publication date:
2019-05-02
Acceptance date:
2019-05-01
DOI:
EISSN:
1768-3254
ISSN:
0223-5234
Pmid:
31103897
Language:
English
Keywords:
Pubs id:
pubs:1004617
UUID:
uuid:0d152344-d814-4301-9f7b-6b0f6ea2b9ae
Local pid:
pubs:1004617
Source identifiers:
1004617
Deposit date:
2019-07-30

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