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Mixed effects approach to the analysis of the stepped wedge cluster randomised trial—Investigating the confounding effect of time through simulation

Abstract:

Background

A stepped wedge cluster randomised trial (SWCRT) is a multicentred study which allows an intervention to be rolled out at sites in a random order. Once the intervention is initiated at a site, all participants within that site remain exposed to the intervention for the remainder of the study.

The time since the start of the study (“calendar time”) may affect outcome measures through underlying time trends or periodicity. The time since the intervention was introduc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0208876

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0001-8534-116X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
All Souls College
Role:
Author
ORCID:
0000-0001-6324-6559
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0002-9928-8934
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
13
Issue:
12
Pages:
e0208876
Publication date:
2018-12-13
Acceptance date:
2018-11-22
DOI:
EISSN:
1932-6203
Source identifiers:
952741
Language:
English
Pubs id:
pubs:952741
UUID:
uuid:0cfec58f-f34f-4370-a517-19d522bfcdb5
Local pid:
pubs:952741
Deposit date:
2018-12-16

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