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Serine ADP-ribosylation reversal by the hydrolase ARH3

Abstract:

ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of ADPr, and also specify how and when the modification is conjugated to the targets. We recently discovered a new form of ADPr that is attached to serine residues in target proteins (Ser-ADPr) and showed that this PTM is specifically made by PARP1/HP...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.28533

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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More from this funder
Funding agency for:
Ahel, I
Grant:
281739
More from this funder
Funding agency for:
Ahel, I
Grant:
281739
More from this funder
Funding agency for:
Ahel, I
Grant:
281739
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Article number:
e28533
Publication date:
2017-06-26
DOI:
ISSN:
2050-084X
Pmid:
28650317
Language:
English
Keywords:
Pubs id:
pubs:702211
UUID:
uuid:0cf73903-b659-44ae-ad43-ebafd7bb9a65
Local pid:
pubs:702211
Deposit date:
2017-09-08

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