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Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches

Abstract:

Mycobacterium africanum (Maf) causes a substantial proportion of human tuberculosis in some countries of West Africa, but little is known on this pathogen. We compared the genomes of 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve neutrally in L5 but under purifying selection in L6. Even though over 90% of the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-8982-9488
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Role:
Author
ORCID:
0000-0003-0752-0538
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
ORCID:
0000-0002-4162-0228
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Role:
Author
ORCID:
0000-0001-8929-193X
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Name:
European Research Council
Grant:
309540
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Name:
Swiss National Science Foundation
Grant:
310030
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Name:
Wellcome Trust
Grant:
097134/Z/11/Z
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
8
Article number:
11269
Publication date:
2018-07-26
Acceptance date:
2018-07-16
DOI:
EISSN:
2045-2322
Pmid:
30050166
Language:
English
Keywords:
Pubs id:
pubs:897540
UUID:
uuid:0cd30e03-1c4d-4667-996e-1baf3cc91cdb
Local pid:
pubs:897540
Source identifiers:
897540
Deposit date:
2019-07-03

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