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The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial

Abstract:

Depressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications. Personalised medicine offers a means of reducing this delay; however, the clinical effectiveness of personalised approaches to antidepressant treatment has not previously been tested. We assessed the clinical effectiveness of using a predictive algorithm, based on behavioural tests of affective cognition and subjective symptoms, to guide antidepressant treat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41386-021-00981-z

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0001-9108-3144
Publisher:
Springer Nature
Journal:
Neuropsychopharmacology More from this journal
Volume:
46
Pages:
1307-1314
Publication date:
2021-02-26
Acceptance date:
2021-01-27
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
Language:
English
Keywords:
Pubs id:
1159020
Local pid:
pubs:1159020
Deposit date:
2021-01-28

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