Journal article
A longitudinal magnetoencephalographic study of the effects of deep brain stimulation on neuronal dynamics in severe anorexia nervosa
- Abstract:
- Anorexia Nervosa (AN) is a debilitating psychiatric disorder characterized by the relentless pursuit of thinness, leading to severe emaciation. Magnetoencephalography (MEG)was used to record the neuronal response in seven patients with treatment-resistant AN while completing a disorder-relevant food wanting task. The patients underwent a 15-month protocol, where MEG scans were conducted pre-operatively, post-operatively prior to deep brain stimulation (DBS) switch on, twice during a blind on/off month and at protocol end. Electrodes were implanted bilaterally into the nucleus accumbens with stimulation at the anterior limb of the internal capsule using rechargeable implantable pulse generators. Three patients met criteria as responders at 12 months of stimulation, showing reductions of eating disorder psychopathology of over 35%. An increase in alpha power, as well as evoked power at latencies typically associated with visual processing, working memory, and contextual integration was observed in ON compared to OFF sessions across all seven patients. Moreover, an increase in evoked power at P600-like latencies as well as an increase in γ-band phase-locking over anterior-to-posterior regions were observed for high- compared to low-calorie food image only in ON sessions. These findings indicate that DBS modulates neuronal process in regions far outside the stimulation target site and at latencies possibly reflecting task specific processing, thereby providing further evidence that deep brain stimulation can play a role in the treatment of otherwise intractable psychiatric disorders.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.5MB, Terms of use)
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- Publisher copy:
- 10.3389/fnbeh.2022.841843
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Behavioral Neuroscience More from this journal
- Volume:
- 16
- Article number:
- 841843
- Publication date:
- 2022-05-18
- Acceptance date:
- 2022-04-22
- DOI:
- EISSN:
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1662-5153
- ISSN:
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1662-5153
- Pmid:
-
35692383
- Language:
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English
- Keywords:
- Pubs id:
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1265199
- Local pid:
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pubs:1265199
- Deposit date:
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2022-07-14
Terms of use
- Copyright holder:
- Braeutigam et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 Braeutigam, Scaife, Aziz and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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