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Journal article

Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

Abstract:
An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation of reaction conditions. These systems display both weak antibacterial activity and proteasome inhibition.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c7ob01148b

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
Publisher:
Royal Society of Chemistry
Journal:
Organic and Biomolecular Chemistry More from this journal
Volume:
15
Issue:
25
Pages:
5373-5379
Publication date:
2017-06-15
Acceptance date:
2017-06-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Language:
English
Pubs id:
pubs:701541
UUID:
uuid:0ca53d31-83ad-44fa-97f6-f1114995a61b
Local pid:
pubs:701541
Source identifiers:
701541
Deposit date:
2017-06-23

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