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Exploitation of sub-micron cavitation nuclei to enhance ultrasound-mediated transdermal transport and penetration of vaccines

Abstract:

Inertial cavitation mediated by ultrasound has been previously shown to enable skin permeabilisation for transdermal drug and vaccine delivery, by sequentially applying the ultrasound then the therapeutic in liquid form on the skin surface. Using a novel hydrogel dosage form, we demonstrate that the use of sub-micron gas-stabilising polymeric nanoparticles (nanocups) to sustain and promote cavitation activity during simultaneous application of both drug and vaccine results in a significant en...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jconrel.2016.07.016

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Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Department:
Oxford, MPLS, Engineering Science
Role:
Author
More by this author
Department:
Oxford, MPLS, Engineering Science
Role:
Author
More by this author
Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Grant:
Digital Economy Programme (EP/G036861/1)
Oxford Martin School More from this funder
Oxford Centre for Drug Delivery Devices More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Controlled Release Journal website
Volume:
238
Pages:
22-30
Publication date:
2016-07-11
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
Pubs id:
pubs:634829
URN:
uri:0c9c54e7-48cf-46c1-bc47-0f692450cd57
UUID:
uuid:0c9c54e7-48cf-46c1-bc47-0f692450cd57
Local pid:
pubs:634829

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