Journal article
Exploitation of sub-micron cavitation nuclei to enhance ultrasound-mediated transdermal transport and penetration of vaccines
- Abstract:
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Inertial cavitation mediated by ultrasound has been previously shown to enable skin permeabilisation for transdermal drug and vaccine delivery, by sequentially applying the ultrasound then the therapeutic in liquid form on the skin surface. Using a novel hydrogel dosage form, we demonstrate that the use of sub-micron gas-stabilising polymeric nanoparticles (nanocups) to sustain and promote cavitation activity during simultaneous application of both drug and vaccine results in a significant en...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.2MB)
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- Publisher copy:
- 10.1016/j.jconrel.2016.07.016
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Authors
Funding
Oxford Centre for Drug Delivery Devices
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Oxford Martin School
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Controlled Release Journal website
- Volume:
- 238
- Pages:
- 22-30
- Publication date:
- 2016-07-11
- Acceptance date:
- 2016-07-10
- DOI:
- EISSN:
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1873-4995
- ISSN:
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0168-3659
- Pmid:
-
27417040
- Source identifiers:
-
634829
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:634829
- UUID:
-
uuid:0c9c54e7-48cf-46c1-bc47-0f692450cd57
- Local pid:
- pubs:634829
- Deposit date:
- 2016-09-01
Terms of use
- Copyright holder:
- Bhatnagar et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. Under a Creative Commons license.
- Licence:
- CC Attribution (CC BY)
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