- Abstract:
-
Inertial cavitation mediated by ultrasound has been previously shown to enable skin permeabilisation for transdermal drug and vaccine delivery, by sequentially applying the ultrasound then the therapeutic in liquid form on the skin surface. Using a novel hydrogel dosage form, we demonstrate that the use of sub-micron gas-stabilising polymeric nanoparticles (nanocups) to sustain and promote cavitation activity during simultaneous application of both drug and vaccine results in a significant en...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.2MB)
-
- Publisher copy:
- 10.1016/j.jconrel.2016.07.016
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Controlled Release Journal website
- Volume:
- 238
- Pages:
- 22-30
- Publication date:
- 2016-07-11
- DOI:
- EISSN:
-
1873-4995
- ISSN:
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0168-3659
- Pubs id:
-
pubs:634829
- URN:
-
uri:0c9c54e7-48cf-46c1-bc47-0f692450cd57
- UUID:
-
uuid:0c9c54e7-48cf-46c1-bc47-0f692450cd57
- Local pid:
- pubs:634829
- Language:
- English
- Keywords:
- Copyright holder:
- Bhatnagar et al.
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. Under a Creative Commons license.
Journal article
Exploitation of sub-micron cavitation nuclei to enhance ultrasound-mediated transdermal transport and penetration of vaccines
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Oxford Martin School
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