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Proton movement and coupling in the POT family of peptide transporters

Abstract:

POT transporters represent an evolutionarily well-conserved family of proton-coupled transport systems in biology. An unusual feature of the family is their ability to couple the transport of chemically diverse ligands to an inwardly directed proton electrochemical gradient. For example, in mammals, fungi, and bacteria they are predominantly peptide transporters, whereas in plants the family has diverged to recognize nitrate, plant defense compounds, and hormones. Although recent structural a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1710727114

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Funding agency for:
Newstead, S
Grant:
Investigator Award 102890/Z/ 13/Z
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Grant:
Z.W
R01GM053148(toG.A.V.,J.M.J.S.,C.L.,
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
114
Issue:
50
Pages:
13182-13187
Publication date:
2018-11-27
Acceptance date:
2017-11-03
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
29180426
Source identifiers:
803119
Language:
English
Keywords:
Pubs id:
pubs:803119
UUID:
uuid:0c88fcca-f89c-40aa-ab43-5a90bea20508
Local pid:
pubs:803119
Deposit date:
2018-08-11

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