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The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4

Abstract:

Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically manipulating primary macrophages. We developed an effective genetic approach to manipulate the sub-cellular distribution of CD4 in macrophages, and investigated how this affects the HIV-1 entry pathway. Pluripotent Stem Cells (PSC) were transduced with lentiviral vectors designed to manipulate CD4 location and were then differentiated int...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0086071

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Linacre College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
9
Issue:
1
Pages:
e86071
Publication date:
2014-01-22
DOI:
EISSN:
1932-6203
Pubs id:
pubs:447868
URN:
uri:0c81c4af-883d-45dd-8ac4-7c50ed9daa06
UUID:
uuid:0c81c4af-883d-45dd-8ac4-7c50ed9daa06
Local pid:
pubs:447868
Paper number:
1

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