Journal article
The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4
- Abstract:
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Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically manipulating primary macrophages. We developed an effective genetic approach to manipulate the sub-cellular distribution of CD4 in macrophages, and investigated how this affects the HIV-1 entry pathway. Pluripotent Stem Cells (PSC) were transduced with lentiviral vectors designed to manipulate CD4 location and were then differentiated int...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 770.2KB)
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- Publisher copy:
- 10.1371/journal.pone.0086071
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Authors
Funding
Medical Research Council
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- e86071
- Publication date:
- 2014-01-22
- Acceptance date:
- 2013-12-05
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Pmid:
-
24465876
- Source identifiers:
-
447868
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:447868
- UUID:
-
uuid:0c81c4af-883d-45dd-8ac4-7c50ed9daa06
- Local pid:
- pubs:447868
- Deposit date:
- 2017-11-12
Terms of use
- Copyright holder:
- van Wilgenburg et al
- Copyright date:
- 2014
- Notes:
- © 2014 van Wilgenburg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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