- Abstract:
-
Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically manipulating primary macrophages. We developed an effective genetic approach to manipulate the sub-cellular distribution of CD4 in macrophages, and investigated how this affects the HIV-1 entry pathway. Pluripotent Stem Cells (PSC) were transduced with lentiviral vectors designed to manipulate CD4 location and were then differentiated int...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 770.2KB)
-
- Publisher copy:
- 10.1371/journal.pone.0086071
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- e86071
- Publication date:
- 2014-01-22
- DOI:
- EISSN:
-
1932-6203
- Pubs id:
-
pubs:447868
- URN:
-
uri:0c81c4af-883d-45dd-8ac4-7c50ed9daa06
- UUID:
-
uuid:0c81c4af-883d-45dd-8ac4-7c50ed9daa06
- Local pid:
- pubs:447868
- Paper number:
- 1
- Language:
- English
- Keywords:
- Copyright holder:
- van Wilgenburg et al.
- Copyright date:
- 2014
- Notes:
- © 2014 van Wilgenburg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4
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