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The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast

Abstract:

Protein-DNA complexes can impede DNA replication and cause replication fork collapse. Whilst it is known that homologous recombination is deployed in such instances to restart replication, it is unclear how a stalled fork transitions into a collapsed fork at which recombination proteins can load. Previously we established assays in Schizosaccharomyces pombe for studying recombination induced by replication fork collapse at the site-specific protein-DNA barrier RTS1 (Nguyen et al., 2015). Here...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.47277.001

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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Article number:
e47277
Publication date:
2019-05-31
Acceptance date:
2019-04-14
DOI:
EISSN:
2050-084X
Source identifiers:
998951
Keywords:
Pubs id:
pubs:998951
UUID:
uuid:0c7dc304-4288-400d-a1f0-21293d0f1b13
Local pid:
pubs:998951
Deposit date:
2019-05-16

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