Journal article
A high-sensitivity HPLC assay for measuring intracellular Na(+) and K(+) and its application to Plasmodium falciparum infected erythrocytes.
- Abstract:
- The measurement of intracellular ion concentrations, and the screening of chemical agents to identify molecules targeting ion transport, has traditionally involved low-throughput techniques. Here we present a novel HPLC method that allows the rapid, high-sensitivity measurement of cell Na(+) and K(+) content, demonstrating its utility by monitoring the ionic changes induced in the intracellular malaria parasite by the new spiroindolone antimalarial KAE609.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
German Academic Exchange Service
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Australian National Health and Medical Research Council
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 6
- Issue:
- 1
- Pages:
- 29241
- Publication date:
- 2016-07-07
- Acceptance date:
- 2016-06-14
- DOI:
- EISSN:
-
2045-2322
- ISSN:
-
2045-2322
- Pmid:
-
27385291
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:629980
- UUID:
-
uuid:0c77387f-1155-42ed-8f56-252d35b2dbd9
- Local pid:
- pubs:629980
- Source identifiers:
-
629980
- Deposit date:
- 2018-01-22
Terms of use
- Copyright holder:
- Winterberg and Kirk
- Copyright date:
- 2016
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder
- Licence:
- CC Attribution (CC BY)
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