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Thesis

Investigating the role of IGF-1R in the cellular response to DNA damage

Abstract:

IGF-1R plays an important role in regulating cell proliferation, survival and migration. Its overexpression in a number of cancers has been associated with radio-resistance. Previous studies from our group and others have confirmed that depletion or inhibition of IGF 1R can sensitise cancer cells to ionising radiation. However, the underlying mechanisms remain elusive. Our study aimed to uncover the mechanisms of radio-sensitisation associated with the IGF-1R signalling pathway. This was a...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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