Investigating the role of IGF-1R in the cellular response to DNA damage

Thesis

IGF-1R plays an important role in regulating cell proliferation, survival and migration. Its overexpression in a number of cancers has been associated with radio-resistance. Previous studies from our group and others have confirmed that depletion or inhibition of IGF 1R can sensitise cancer cells to ionising radiation. However, the underlying mechanisms remain elusive. Our study aimed to uncover the mechanisms of radio-sensitisation associated with the IGF-1R signalling pathway. This was a...

Expand abstract

Authors: Petnga Kamdoum, WV

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: IGF-1R signalling and the response to radiotherapy; Generating IGF-1R mutants clones; Type I insulin-like growth factor receptor; Growth factor receptor signalling and DNA damage; Growth factor receptor kinases and the response to irradiation; IGF-1R and DNA damage; CRISPR-genome editing the IGF-1R gene
• Subjects: Cellular response to irradiation in IGF-1R mutant clones; Investigating the role of IGF-1R in the cellular response to DNA damage