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PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies

Abstract:

The carotid body is a peripheral chemoreceptor that plays a central role in mammalian oxygen homeostasis. In response to sustained hypoxia, it manifests rapid cellular proliferation and an associated increase in responsiveness to hypoxia. Understanding the cellular and molecular mechanisms underlying these processes is of interest both to specialised chemoreceptive functions of that organ and potentially to the general physiology and pathophysiology of cellular hypoxia. We have combined cell ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1113/JP275996

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
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Grant:
106241/Z/14/Z
FC001501
Publisher:
The Physiological Society Publisher's website
Journal:
Journal of Physiology Journal website
Publication date:
2018-05-19
Acceptance date:
2018-05-17
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pubs id:
pubs:858422
URN:
uri:0c3cc40e-ff24-482d-8e19-756dcd8f9cb7
UUID:
uuid:0c3cc40e-ff24-482d-8e19-756dcd8f9cb7
Local pid:
pubs:858422

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