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PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies

Abstract:

The carotid body is a peripheral chemoreceptor that plays a central role in mammalian oxygen homeostasis. In response to sustained hypoxia, it manifests rapid cellular proliferation and an associated increase in responsiveness to hypoxia. Understanding the cellular and molecular mechanisms underlying these processes is of interest both to specialised chemoreceptive functions of that organ and potentially to the general physiology and pathophysiology of cellular hypoxia. We have combined cell ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/JP275996

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine
Role:
Author
More from this funder
Name:
Medical Research Council
Grant:
FC001501
More from this funder
Name:
Cancer Research UK
Grant:
FC001501
More from this funder
Name:
Wellcome Trust
Grant:
FC001501
More from this funder
Name:
Ludwig Institute for Cancer Research
Publisher:
Physiological Society
Journal:
Journal of Physiology More from this journal
Publication date:
2018-05-19
Acceptance date:
2018-05-17
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Keywords:
Pubs id:
pubs:858422
UUID:
uuid:0c3cc40e-ff24-482d-8e19-756dcd8f9cb7
Local pid:
pubs:858422
Source identifiers:
858422
Deposit date:
2018-06-20

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