Journal article icon

Journal article

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

Abstract:

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types (CD14+ monocytes, CD16+ neutrophils, and naive CD4+ T cells) from up to 197 individuals. We assess, quantitatively, the relative contribution of cis-genetic and epigenetic factors to transcription and evaluate their impact ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More from this funder
Name:
Wellcome Trust
Grant:
WT098051
WT091310
257082
More from this funder
Name:
British Heart Foundation
Grant:
RE/13/6/30180
RG/08/014/24067
RG/09/012/28096
RG/13/13/30194
More from this funder
Name:
Lundbeck Foundation
Grant:
R182-2014-3881
R193-2015-1611
More from this funder
Name:
Department of Health
Grant:
NF-SI-0510-10214
NF-SI-0512-10165
NF-SI-0513-10151
RP-PG-0310-1002
More from this funder
Name:
Medical Research Council
Grant:
975281
MR/L003120/1
1365667
G0800270
Publisher:
Elsevier
Journal:
Cell More from this journal
Volume:
167
Issue:
5
Pages:
1398-1414.e24
Publication date:
2016-11-17
Acceptance date:
2016-10-14
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
27863251
Language:
English
Keywords:
Pubs id:
pubs:713521
UUID:
uuid:0c29498c-d581-4c7b-aa22-5b9bf3b5b718
Local pid:
pubs:713521
Source identifiers:
713521
Deposit date:
2019-04-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP