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Modelling late-onset diseases with induced pluripotent stem cells: a matter of time management

Abstract:

The advent of induced pluripotent stem cells (iPSC) has revolutionised in vitro modelling of many intractable human diseases. By deriving iPSC from individuals with progressive disease, it has been possible to capture disease-associated genes and study their impact on the downstream function of terminally-differentiated cell types. Nevertheless, late onset diseases pose particular challenges for disease modelling given the protracted time frame over which they normally develop. Such practi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18609/cgti.2021.015

Authors


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Institution:
University of Oxford
Division:
MSD
Sub department:
Pathology Dunn School
Role:
Author
Publisher:
Bioinsights Publisher's website
Journal:
Cell and Gene Therapy Insights Journal website
Volume:
7
Issue:
1
Pages:
51-62
Publication date:
2021-02-15
Acceptance date:
2021-02-02
DOI:
Language:
English
Keywords:
Pubs id:
1161560
Local pid:
pubs:1161560
Deposit date:
2021-02-15

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