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Simian adenoviruses as vaccine vectors

Abstract:

Replication incompetent human adenovirus serotype 5 has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and non-replicating cells, have a broad tissue tropism, elicit high immune responses and are easily purified to high titres. However, the utility of HAdV-C5 vectors as potential vaccines is limited due to pre-existing immunity within the human population which significantly reduces the immunogenicity of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2217/fvl-2016-0070

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Publisher:
Future Medicine
Journal:
Future Virology More from this journal
Volume:
11
Issue:
9
Pages:
649–659
Publication date:
2016-09-15
Acceptance date:
2016-08-19
DOI:
ISSN:
1746-0794 and 1746-0808
Keywords:
Pubs id:
pubs:641725
UUID:
uuid:0bdfc9ef-e39c-42cb-8b89-6d15fe01c5c2
Local pid:
pubs:641725
Deposit date:
2016-09-08

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