Journal article icon

Journal article

Structural characterisation of KKT4, an unconventional microtubule-binding kinetochore protein

Abstract:

The kinetochore is the macromolecular machinery that drives chromosome segregation by interacting with spindle microtubules. Kinetoplastids (such as Trypanosoma brucei), a group of evolutionarily divergent eukaryotes, have a unique set of kinetochore proteins that lack any significant homology to canonical kinetochore components. To date, KKT4 is the only kinetoplastid kinetochore protein that is known to bind microtubules. Here we use X-ray crystallography, NMR spectroscopy, and crosslinking...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.str.2021.04.004

Authors


Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
Structure Journal website
Volume:
29
Issue:
9
Pages:
1014-1028.E8
Publication date:
2021-04-28
Acceptance date:
2021-04-08
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
1170857
Local pid:
pubs:1170857
Deposit date:
2021-04-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP