Journal article
Structural characterisation of KKT4, an unconventional microtubule-binding kinetochore protein
- Abstract:
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The kinetochore is the macromolecular machinery that drives chromosome segregation by interacting with spindle microtubules. Kinetoplastids (such as Trypanosoma brucei), a group of evolutionarily divergent eukaryotes, have a unique set of kinetochore proteins that lack any significant homology to canonical kinetochore components. To date, KKT4 is the only kinetoplastid kinetochore protein that is known to bind microtubules. Here we use X-ray crystallography, NMR spectroscopy, and crosslinking...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 5.2MB)
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- Publisher copy:
- 10.1016/j.str.2021.04.004
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 29
- Issue:
- 9
- Pages:
- 1014-1028.E8
- Publication date:
- 2021-04-28
- Acceptance date:
- 2021-04-08
- DOI:
- EISSN:
-
1878-4186
- ISSN:
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0969-2126
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1170857
- Local pid:
- pubs:1170857
- Deposit date:
- 2021-04-09
Terms of use
- Copyright holder:
- Ludzia et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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