Conference item
Thymosin beta 4 - a novel regulator of low density lipoprotein receptor related protein 1 (LRP1) in vascular disease
- Abstract:
-
Vascular stability and tone are maintained by contractile smooth muscle cells (VSMCs). Injury-induced growth factors stimulate a phenotypic switching of VSMCs, from their quiescent contractile state to a more active synthetic phenotype that proliferate and migrate. Chronic VSMC dedifferentiation leads to vascular thickening and stiffness, exacerbates inflammation and promotes atherosclerotic lesion development and susceptibility to abdominal aortic aneurysm (AAA). Inhibiting VSMC phenotypic t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Host title:
- HEART
- Journal:
- Heart Journal website
- Volume:
- 105
- Issue:
- Supplement 6
- Article number:
- 182
- Publication date:
- 2019-05-01
- Acceptance date:
- 2019-04-01
- Event title:
- .
- DOI:
- EISSN:
-
1468-201X
- ISSN:
-
1355-6037
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1025947
- Local pid:
- pubs:1025947
- Deposit date:
- 2021-02-01
Terms of use
- Copyright holder:
- BMJ Publishing Group Limited
- Copyright date:
- 2019
- Rights statement:
- © 2019, Published by the BMJ Publishing Group Limited.
- Notes:
- This is the accepted manuscript version of the conference paper. The final published version is available from BMJ Publishing Group at 10.1136/heartjnl-2019-BCS.225
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