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Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

Abstract:

Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice, overlapping regions of chromosome 3 have been associated with susceptibility to IBD-like pathology, including a locus called Hiccs. However, the specific gene that controls disease susceptibility remains unknown. Here we identify a Hiccs locus gene, Alpk1 (encoding alpha kinase 1), as a potent regulator of intestinal inflammation. In res...

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Publication status:
Published
Peer review status:
Peer reviewed

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Powrie, F
Grant:
(2013)3687660
More from this funder
Name:
European Research Council
Funding agency for:
Powrie, F
Grant:
(2013)3687660
More from this funder
Name:
Cancer Research
Funding agency for:
Franchini, F
Grant:
OCRC-DPhil13- FF
More from this funder
Name:
Irvington Institute Postdoctoral Fellowship
Funding agency for:
West, N
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
9
Article number:
3797
Publication date:
2018-09-18
Acceptance date:
2018-08-02
DOI:
EISSN:
2041-1723
Pubs id:
pubs:920782
UUID:
uuid:0bb47ebe-43bc-4664-bae0-d703aec9e49b
Local pid:
pubs:920782
Deposit date:
2018-09-21

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