Journal article
Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
- Abstract:
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Binding of serum proteins to polyelectrolyte gene delivery complexes is thought to be an important factor limiting bloodstream circulation and restricting access to target tissues. Protein binding can also inhibit transfection activity in vitro. In this study a multivalent reactive hydrophilic polymer has been used to inhibit protein binding. This polymer is based on poly-[N-(2-hydroxypropyl)methacrylamide] (pHPMA) bearing pendent oligopeptide (Gly-Phe-Leu-Gly) side chains terminated in react...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 782.7KB)
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- Publisher copy:
- 10.1074/jbc.275.6.3793
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Authors
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 275
- Issue:
- 6
- Pages:
- 3793-3802
- Publication date:
- 2000-02-11
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Source identifiers:
-
709405
Item Description
- Keywords:
- Pubs id:
-
pubs:709405
- UUID:
-
uuid:0ba905f3-7c70-4014-808f-f39ba599b3d2
- Local pid:
- pubs:709405
- Deposit date:
- 2017-07-27
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology, Inc
- Copyright date:
- 2000
- Notes:
- © Copyright 2019 American Society for Biochemistry and Molecular Biology
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