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Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin

Abstract:

Binding of serum proteins to polyelectrolyte gene delivery complexes is thought to be an important factor limiting bloodstream circulation and restricting access to target tissues. Protein binding can also inhibit transfection activity in vitro. In this study a multivalent reactive hydrophilic polymer has been used to inhibit protein binding. This polymer is based on poly-[N-(2-hydroxypropyl)methacrylamide] (pHPMA) bearing pendent oligopeptide (Gly-Phe-Leu-Gly) side chains terminated in react...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.275.6.3793

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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
275
Issue:
6
Pages:
3793-3802
Publication date:
2000-02-11
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
709405
Keywords:
Pubs id:
pubs:709405
UUID:
uuid:0ba905f3-7c70-4014-808f-f39ba599b3d2
Local pid:
pubs:709405
Deposit date:
2017-07-27

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