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RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally

Abstract:

The RTS,S/AS01 malaria vaccine encompasses the central repeats and C-terminal of Plasmodium falciparum circumsporozoite protein (PfCSP). Although no Phase II clinical trial studies observed evidence of strain-specific immunity, recent studies show a decrease in vaccine efficacy against nonvaccine strain parasites. In light of goals to reduce malaria morbidity, anticipating the effectiveness of RTS,S/AS01 is critical to planning widespread vaccine introduction. We deep sequenced C-terminal Pfc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; BDI-NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Name:
Wellcome Trust
Grant:
100956/Z/13/Z
More from this funder
Name:
National Institutes of Health
Grant:
2U19AI089680
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Name:
Johns Hopkins Malaria Research Institute
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Name:
Johns Hopkins Bloomberg School of Public Health
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
8
Pages:
6622
Publication date:
2018-04-26
Acceptance date:
2018-03-29
DOI:
ISSN:
2045-2322
Pubs id:
pubs:844455
UUID:
uuid:0ba79d14-ec43-46ae-9b86-de641feef39e
Local pid:
pubs:844455
Source identifiers:
844455
Deposit date:
2018-05-03

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