Journal article
RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally
- Abstract:
-
The RTS,S/AS01 malaria vaccine encompasses the central repeats and C-terminal of Plasmodium falciparum circumsporozoite protein (PfCSP). Although no Phase II clinical trial studies observed evidence of strain-specific immunity, recent studies show a decrease in vaccine efficacy against nonvaccine strain parasites. In light of goals to reduce malaria morbidity, anticipating the effectiveness of RTS,S/AS01 is critical to planning widespread vaccine introduction. We deep sequenced C-terminal Pfc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Johns Hopkins Malaria Research Institute
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Bloomberg Philanthropies
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Johns Hopkins Bloomberg School of Public Health
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Pages:
- 6622
- Publication date:
- 2018-04-26
- Acceptance date:
- 2018-03-29
- DOI:
- ISSN:
-
2045-2322
Item Description
- Pubs id:
-
pubs:844455
- UUID:
-
uuid:0ba79d14-ec43-46ae-9b86-de641feef39e
- Local pid:
- pubs:844455
- Source identifiers:
-
844455
- Deposit date:
- 2018-05-03
Terms of use
- Copyright holder:
- Zhu et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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